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Timing the catch

Nature Structural & Molecular Biology volume 11, pages 68 (2004) | Download Citation

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The mitochondrial 70 kDa heat shock protein (mtHsp70) drives the import of presequence-containing polypeptides into the matrix of mitochondria. A new essential component of the import motor was discovered that regulates the ATP hydrolysis activity of mtHsp70, thereby timing its binding to the incoming polypeptide chain.

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Author information

Affiliations

  1. The author is at Zentrum für Molekulare Biologie, Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. M.Mayer@zmbh.uni-heidelberg.de

    • Matthias P Mayer

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DOI

https://doi.org/10.1038/nsmb0104-6

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