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Sculpting a domain by splicing

Nature Structural & Molecular Biology volume 11, pages 45 (2004) | Download Citation

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A recent study demonstrates that a short insert from alternative splicing in a common protein domain leads to rearrangements of surface loops and domain fold. The results provide a structural basis for the change of functional properties associated with alternative splicing.

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Acknowledgements

We thank J. Rizo for providing the atomic coordinates of the long C2A prior to publication.

Author information

Affiliations

  1. Bazbek Davletov is in the MRC Laboratory of Molecular Biology, Cambridge, UK. baz@mrc-lmb.cam.ac.uk

    • Bazbek Davletov
  2. José L. Jiménez is in the Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, London, UK. jimenez@cancer.org.uk

    • José L Jiménez

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DOI

https://doi.org/10.1038/nsmb0104-4

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