Commentary | Published:

Whither structural biology?

Nature Structural & Molecular Biology volume 11, pages 1215 (2004) | Download Citation

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We know the basic principles of protein, RNA and DNA structure, and we have atomic coordinates of many proteins and RNAs. Structural biology must now expand the range of length and timescales on which we can represent the molecular reality of a cell. Structural molecular biology and structural cell biology must merge into a single discipline, and we must establish a lively intellectual complementarity with the nascent 'systems biology' of the cell.

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Author information

Affiliations

  1. The author is at the Howard Hughes Medical Institute, Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115, USA. harrison@crystal.harvard.edu

    • Stephen C Harrison

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DOI

https://doi.org/10.1038/nsmb0104-12

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