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Paraspeckles: nuclear nests helping to raise mature miRNAs

Nature Structural & Molecular Biology volume 24, pages 783–784 (2017)Cite this article

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The cellular crosstalk between different classes of regulatory noncoding RNAs has reached a new spatial dimension. Jiang et al. reveal an essential role of a nuclear-paraspeckle-organizing long noncoding RNA and its protein partners in regulating the first steps of microRNA biogenesis.

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Figure 1: A nest model of NEAT1-mediated enhancement of miRNA biogenesis.

References

  1. Fatica, A. & Bozzoni, I. Nat. Rev. Genet. 15, 7–21 (2014).

    Article  CAS  Google Scholar 

  2. Fabian, M.R., Sonenberg, N. & Filipowicz, W. Annu. Rev. Biochem. 79, 351–379 (2010).

    Article  CAS  Google Scholar 

  3. Krol, J. et al. Nat. Commun. 6, 7305 (2015).

    Article  CAS  Google Scholar 

  4. Liz, J. et al. Mol. Cell 55, 138–147 (2014).

    Article  CAS  Google Scholar 

  5. Cesana, M. et al. Cell 147, 358–369 (2011).

    Article  CAS  Google Scholar 

  6. Wang, Y. et al. Dev. Cell 25, 69–80 (2013).

    Article  CAS  Google Scholar 

  7. Kallen, A.N. et al. Mol. Cell 52, 101–112 (2013).

    Article  CAS  Google Scholar 

  8. Jiang, L. et al. Nat. Struct. Mol. Biol. 24, 816–824 (2017).

    Article  CAS  Google Scholar 

  9. Kim, V.N., Han, J. & Siomi, M.C. Nat. Rev. Mol. Cell Biol. 10, 126–139 (2009).

    Article  CAS  Google Scholar 

  10. Krol, J., Loedige, I. & Filipowicz, W. Nat. Rev. Genet. 11, 597–610 (2010).

    Article  CAS  Google Scholar 

  11. Ha, M. & Kim, V.N. Nat. Rev. Mol. Cell Biol. 15, 509–524 (2014).

    Article  CAS  Google Scholar 

  12. Fox, A.H. et al. Curr. Biol. 12, 13–25 (2002).

    Article  CAS  Google Scholar 

  13. Fox, A.H., Bond, C.S. & Lamond, A.I. Mol. Biol. Cell 16, 5304–5315 (2005).

    Article  CAS  Google Scholar 

  14. Prasanth, K.V. et al. Cell 123, 249–263 (2005).

    Article  CAS  Google Scholar 

  15. Clemson, C.M. et al. Mol. Cell 33, 717–726 (2009).

    Article  CAS  Google Scholar 

  16. Sunwoo, H. et al. Genome Res. 19, 347–359 (2009).

    Article  CAS  Google Scholar 

  17. Naganuma, T. et al. EMBO J. 31, 4020–4034 (2012).

    Article  CAS  Google Scholar 

  18. Dhir, A., Dhir, S., Proudfoot, N.J. & Jopling, C.L. Nat. Struct. Mol. Biol. 22, 319–327 (2015).

    Article  CAS  Google Scholar 

  19. Chen, L.-L. & Carmichael, G.G. Mol. Cell 35, 467–478 (2009).

    Article  CAS  Google Scholar 

  20. Zhang, X. et al. Cell 158, 607–619 (2014).

    Article  CAS  Google Scholar 

Download references

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  1. the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Jacek Krol

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  1. Jacek Krol
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Correspondence to Jacek Krol.

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Krol, J. Paraspeckles: nuclear nests helping to raise mature miRNAs. Nat Struct Mol Biol 24, 783–784 (2017). https://doi.org/10.1038/nsmb.3479

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