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Fine-tuning PERK signaling to control cell fate under stress

Nature Structural & Molecular Biology volume 24, pages 789–790 (2017)Cite this article

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PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK–CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.

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Figure 1: Novel regulatory checkpoints of the PERK UPRosome.

Debbie Maizels/Springer Nature

Figure 2: Controlling cell fate under ER stress.

Debbie Maizels/Springer Nature

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Acknowledgements

This work was funded by FONDECYT grant no. 1140549 (to C.H.), Millennium Institute grant no. P09-015-F (to C.H.), FONDAP 15150012 (to C.H.), U.S. Office of Naval Research-Global (ONR-G) N62909-16-1-2003 (to C.H), U.S. Air Force Office of Scientific Research FA9550-16-1-0384 (to C.H.), FONDECYT grant no. 3160461 (to H.U.) and the Seed Project from BNI (to H.U.).

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Authors and Affiliations

  1. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile

    Hery Urra & Claudio Hetz

  2. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile

    Hery Urra & Claudio Hetz

  3. Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile

    Hery Urra & Claudio Hetz

  4. Buck Institute for Research in Aging, Novato, California, USA

    Claudio Hetz

  5. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Claudio Hetz

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  1. Hery Urra
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  2. Claudio Hetz
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Correspondence to Claudio Hetz.

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Urra, H., Hetz, C. Fine-tuning PERK signaling to control cell fate under stress. Nat Struct Mol Biol 24, 789–790 (2017). https://doi.org/10.1038/nsmb.3478

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