Long noncoding (lnc)RNAs are postulated to control diverse biological processes by modulating transcription, yet for most lncRNAs evidence supporting this function has been lacking. A new report describes the role of a novel class of lncRNAs—chromatin-associated enhancer RNAs or cheRNAs—in the regulation of proximal gene expression.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Deveson, I.W., Hardwick, S.A., Mercer, T.R. & Mattick, J.S. Trends Genet. 33, 464–478 (2017).
Liu, G., Mattick, J.S. & Taft, R.J. Cell Cycle 12, 2061–2072 (2013).
Cabili, M.N. et al. Genes Dev. 25, 1915–1927 (2011).
Derrien, T. et al. Genome Res. 22, 1775–1789 (2012).
Kapranov, P. et al. Science 296, 916–919 (2002).
Kapranov, P. et al. Genome Res. 15, 987–997 (2005).
Djebali, S. et al. Nature 489, 101–108 (2012).
Lai, F. et al. Nature 494, 497–501 (2013).
Gayen, S., Maclary, E., Buttigieg, E., Hinten, M. & Kalantry, S. Cell Rep. 11, 1251–1265 (2015).
Gayen, S., Maclary, E., Hinten, M. & Kalantry, S. Proc. Natl. Acad. Sci. USA 113, E309–E318 (2016).
Schmitt, A.M. & Chang, H.Y. Cold Spring Harb. Perspect. Med. http://dx.doi.org/10.1101/cshperspect.a026492 (2017).
Kim, T.K. et al. Nature 465, 182–187 (2010).
Andersson, R. et al. Nature 507, 455–461 (2014).
Li, W., Notani, D. & Rosenfeld, M.G. Nat. Rev. Genet. 17, 207–223 (2016).
Werner, M.S. & Ruthenburg, A.J. Cell Rep. 12, 1089–1098 (2015).
Melgar, M.F., Collins, F.S. & Sethupathy, P. Genome Biol. 12, R113 (2011).
Werner, M.S. et al. Nat. Struct. Mol. Biol. 24, 596–603 (2017).
Qi, L.S. et al. Cell 152, 1173–1183 (2013).
Melé, M. & Rinn, J.L. Mol. Cell 62, 657–664 (2016).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Gayen, S., Kalantry, S. Chromatin-enriched lncRNAs: a novel class of enhancer RNAs. Nat Struct Mol Biol 24, 556–557 (2017). https://doi.org/10.1038/nsmb.3430
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.3430
This article is cited by
-
An Emerging Role for Enhancer RNAs in Brain Disorders
NeuroMolecular Medicine (2024)
-
Modulation of Brain Pathology by Enhancer RNAs in Cerebral Ischemia
Molecular Neurobiology (2021)
-
LncRNA-MALAT1 is a promising biomarker for prognostic evaluation of tongue squamous cell carcinoma
European Archives of Oto-Rhino-Laryngology (2020)