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Promoter interactions direct chromatin folding in embryonic stem cells

Nature Structural & Molecular Biology volume 24, pages 494–495 (2017)Cite this article

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The spatial organization of the genome profoundly influences how genes are regulated in normal development or dysregulated in disease. A new study of the murine HoxB locus illustrates how promoter interactions direct higher-order chromatin folding.

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Figure 1: The strings and binders switch (SBS) model can be used to predict chromatin folding.

Debbie Maizels / Springer Nature

Figure 2: Models of chromatin folding.

Debbie Maizels / Springer Nature

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Acknowledgements

J.G. acknowledges support from the Slovak Grant Agency, VEGA 1/0196/14, APVV-0334-12, and the Austrian Science Fund (FWF), P21437, W1238 and F34.

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Authors and Affiliations

  1. Swastika Sanyal is in the Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.,

    Swastika Sanyal

  2. Lucia Molnarova is in the Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.,

    Lucia Molnarova

  3. Juraj Gregan is in the Department of Genetics, Slovakia and the Department of Chromosome Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.,

    Juraj Gregan

Authors
  1. Swastika Sanyal
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  2. Lucia Molnarova
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  3. Juraj Gregan
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Correspondence to Juraj Gregan.

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The authors declare no competing financial interests.

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Sanyal, S., Molnarova, L. & Gregan, J. Promoter interactions direct chromatin folding in embryonic stem cells. Nat Struct Mol Biol 24, 494–495 (2017). https://doi.org/10.1038/nsmb.3421

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