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Splicing of Ezh1 gets muscle out of stressful situations

As cells undergo terminal differentiation, the composition of Polycomb-repressive complex 2 (PRC2) changes and the histone H3K27 methyltransferase Ezh2 is progressively replaced by its homolog Ezh1. By identifying an enzymatically inactive splice variant of Ezh1 that is sensitive to cellular stress, Bodega et al. now demonstrate that PRC2–Ezh1 has an essential role in establishing an altered gene expression program required for postmitotic muscle cells to adapt to environmental changes.

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Figure 1: Splicing of Ezh1 limits the level of functional PRC2 complex in healthy cells while allowing a rapid adaptive response to oxidative stress.


  1. Geisler, S.J. & Paro, R. Development 142, 2876–2887 (2015).

    Article  CAS  Google Scholar 

  2. Pasini, D. & Di Croce, L. Curr. Opin. Genet. Dev. 36, 50–58 (2016).

    Article  CAS  Google Scholar 

  3. Shen, X. et al. Mol. Cell 32, 491–502 (2008).

    Article  CAS  Google Scholar 

  4. Cao, R. & Zhang, Y. Mol. Cell 15, 57–67 (2004).

    Article  CAS  Google Scholar 

  5. Margueron, R. et al. Nature 461, 762–767 (2009).

    Article  CAS  Google Scholar 

  6. Ezhkova, E. et al. Genes Dev. 25, 485–498 (2011).

    Article  CAS  Google Scholar 

  7. O'Carroll, D. et al. Mol. Cell. Biol. 21, 4330–4336 (2001).

    Article  CAS  Google Scholar 

  8. Margueron, R. et al. Mol. Cell 32, 503–518 (2008).

    Article  CAS  Google Scholar 

  9. Mu, W., Starmer, J., Shibata, Y., Yee, D. & Magnuson, T. Dev. Biol. 424, 198–207 (2017).

    Article  CAS  Google Scholar 

  10. Caretti, G., Di Padova, M., Micales, B., Lyons, G.E. & Sartorelli, V. Genes Dev. 18, 2627–2638 (2004).

    Article  CAS  Google Scholar 

  11. Stojic, L. et al. Epigenetics Chromatin 4, 16 (2011).

    Article  CAS  Google Scholar 

  12. Bodega, B. et al. Nat. Struct. Mol. Biol. 24, 444–452 (2017).

    Article  CAS  Google Scholar 

  13. Xu, B. et al. Blood 125, 346–357 (2015).

    Article  CAS  Google Scholar 

  14. Mousavi, K., Zare, H., Wang, A.H. & Sartorelli, V. Mol. Cell 45, 255–262 (2012).

    Article  CAS  Google Scholar 

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Work in the Brand and Dilworth labs is supported by grants from the Canadian Institutes of Health Research (MOP-82813 to M.B. and FDN-143330 to F.J.D.).

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Correspondence to Marjorie Brand or F Jeffrey Dilworth.

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Brand, M., Dilworth, F. Splicing of Ezh1 gets muscle out of stressful situations. Nat Struct Mol Biol 24, 435–437 (2017).

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