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Carb cutting works better with a partner

Nature Structural & Molecular Biology volume 24, pages 433–435 (2017)Cite this article

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O-GlcNAc is a reversible post-translational modification that is added by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA). OGA is emerging as a therapeutic target for multiple diseases, but its structure has been elusive until now.

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Figure 1: Regulation of the O-GlcNAc post-translational modification.
Figure 2: Structure of OGA.
Figure 3: Inhibition of OGA.

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References

  1. Hart, G.W., Housley, M.P. & Slawson, C. Nature 446, 1017–1022 (2007).

    Article  CAS  Google Scholar 

  2. Hart, G. W. in Glycoscience: Biology and Medicine (eds. Taniguchi, N. et al.) Part XII (Springer Japan, 2015).

    Google Scholar 

  3. Bond, M.R. & Hanover, J.A. Annu. Rev. Nutr. 33, 205–229 (2013).

    Article  CAS  Google Scholar 

  4. Yuzwa, S.A. & Vocadlo, D.J. Chem. Soc. Rev. 43, 6839–6858 (2014).

    Article  CAS  Google Scholar 

  5. Kim, C. et al. Neurobiol. Aging 34, 275–285 (2013).

    Article  CAS  Google Scholar 

  6. Yuzwa, S. A. et al. Mol. Neurodegener. 9, 42 (2014).

    Article  Google Scholar 

  7. Smith, S.M. et al. Alzheimer's and Dementia 12, P261 (2016).

    Article  Google Scholar 

  8. Gloster, T.M. & Vocadlo, D.J. Curr. Signal Transduct. Ther. 5, 74–91 (2010).

    Article  CAS  Google Scholar 

  9. Li, B., Li, H., Lu, L. & Jiang, J. Nat. Struct. Mol. Biol. 24, 362–369 (2017).

    Article  CAS  Google Scholar 

  10. Elsen, N.L. et al. Nat. Chem. Biol. https://dx.doi.org/10.1038/nchembio.2357,(2017).

  11. Roth, C. et al. Nat. Chem. Biol. https://dx.doi.org/10.1038/nchembio.2358,(2017).

  12. Cetinbas¸, N., Macauley, M.S., Stubbs, K.A., Drapala, R. & Vocadlo, D.J. Biochemistry 45, 3835–3844 (2006).

    Article  Google Scholar 

  13. Cekic, N. et al. Chem. Sci. 7, 3742–3750 (2016).

    Article  CAS  Google Scholar 

  14. Yuzwa, S.A. et al. Nat. Chem. Biol. 4, 483–490 (2008).

    Article  CAS  Google Scholar 

  15. Ma, J. & Hart, G.W. Clin. Proteomics 11, 8 (2014).

    Article  Google Scholar 

  16. Lazarus, M.B., Nam, Y., Jiang, J., Sliz, P. & Walker, S. Nature 469, 564–567 (2011).

    Article  CAS  Google Scholar 

  17. Pathak, S. et al. Nat. Struct. Mol. Biol. 22, 744–750 (2015).

    Article  CAS  Google Scholar 

  18. Schimpl, M., Schüttelkopf, A.W., Borodkin, V.S. & van Aalten, D.M.F. Biochem. J. 432, 1–7 (2010).

    Article  CAS  Google Scholar 

  19. Khidekel, N. et al. Nat. Chem. Biol. 3, 339–348 (2007).

    Article  CAS  Google Scholar 

  20. Rexach, J.E. et al. Nat. Chem. Biol. 6, 645–651 (2010).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author acknowledges support from the NIH for related projects in her lab (R21DK112733).

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  1. Jennifer J. Kohler is in the Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.,

    Jennifer J Kohler

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  1. Jennifer J Kohler
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Correspondence to Jennifer J Kohler.

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Kohler, J. Carb cutting works better with a partner. Nat Struct Mol Biol 24, 433–435 (2017). https://doi.org/10.1038/nsmb.3405

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