The binding of foreign peptides to host major histocompatibility complex (MHC) forms the basis of adaptive immune recognition. The MHC and T cell receptors (TCRs) use diverse structural solutions to enhance peptide presentation and recognition, and two new reports provide insights into noncanonical modes of detection and binding.
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Dash, P., Thomas, P. Surveillance states. Nat Struct Mol Biol 24, 339–341 (2017). https://doi.org/10.1038/nsmb.3398
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DOI: https://doi.org/10.1038/nsmb.3398
