a-b. Differential heatmaps at a 100kb resolution are shown for BR#2, on the same regions presented Fig. 1b (a) or for both replicates (BR#1 and BR#2) on additional regions located on chromosome 9 and 20 as indicated (b). Data are expressed as natural log of differential interaction count (normalized, see Online Methods). Arrows indicate DSBs positions. Black and grey bars indicate captured domains positions. The γH2AX profiles (normalized ChIP seq counts, smoothed using 100kb windows) obtained across the same regions by ChIP-seq are shown (middle panels, Aymard, F. et al, Nat Struct Mol Biol. 4, 366-74, 2014). Positions are indicated in bp.