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Unearthing worm replication origins

Nature Structural & Molecular Biology volume 24, pages 195–196 (2017)Cite this article

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Unlike in animals in which gastrulation marks the onset of zygotic transcription and a transition from random to site-specific localization of replication origins, transcription and origin specification in Caenorhabditis elegans are in place before gastrulation. Nonetheless, origin-site redistribution takes place after gastrulation, and is coordinated with changes in the sites of active transcription.

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Figure 1: Different chromatin features are associated with origins at different stages of embryonic development.
Figure 2: Coordination of transcription and replication.

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Authors and Affiliations

  1. Takayo Sasaki and David M. Gilbert are at the Department of Biological Science, Florida State University, Tallahassee, Florida, USA.,

    Takayo Sasaki & David M Gilbert

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  1. Takayo Sasaki
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  2. David M Gilbert
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Correspondence to Takayo Sasaki or David M Gilbert.

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Sasaki, T., Gilbert, D. Unearthing worm replication origins. Nat Struct Mol Biol 24, 195–196 (2017). https://doi.org/10.1038/nsmb.3385

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