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Mechanisms for targeted, purposeful mutation revealed in an APOBEC–DNA complex

Nature Structural & Molecular Biology volume 24, pages 9798 (2017) | Download Citation

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Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic integrity. New structures reported by Harris, Aihara and colleagues offer the first glimpses into the enzyme–DNA complex and reveal both expected and unexpected insights into the DNA-binding mode involved in targeting purposeful mutation.

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Affiliations

  1. Emily K. Schutsky, Zachary M. Hostetler and Rahul M. Kohli are at the Department of Medicine and the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Emily K Schutsky
    • , Zachary M Hostetler
    •  & Rahul M Kohli

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Rahul M Kohli.

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DOI

https://doi.org/10.1038/nsmb.3373

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