Supplementary Figure 5: Lack of X-chromosome inactivation in the absence of Xist. | Nature Structural & Molecular Biology

Supplementary Figure 5: Lack of X-chromosome inactivation in the absence of Xist.

From: Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

Supplementary Figure 5

(a) Each plot represents a candidate X-linked gene that was previously studied in Kalantry et al, 20096. Allele-specific expression ratio of each gene represents the number of reads mapped on paternal genome divided by the total number of paternal and maternal reads. Mean of maternal and paternal reads are respectively represented as a red or a blue line. Percentage of parental origin transcript (top panel) and level of expression in RPRT (bottom panel) of each gene are represented between 8-cell stage and blastocysts.

(b) A table summarizing the total differentially expressed (DE) genes between CB wt and CB Xistpat∆ female embryos during early development and their localization on X chromosomes or autosomes. The percentages shown correspond to the distribution of total DE genes between autosomes and X chromosomes. The blastocyst stage is highlighted in red and candidate DE genes from this stage have been analyzed in Figure 4. List of DE genes is available in Supplementary Data Set 2.

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