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Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

Nature Structural & Molecular Biology volume 23, pages 766769 (2016) | Download Citation

Forceful unfolding by entropic pulling is the general mechanism by which Hsp70 and Hsp110 chaperones control the oligomeric states, structures and activities of cellular proteins.

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Author information

Affiliations

  1. Paolo De Los Rios is at the Institute of Physics, School of Basic Sciences and Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

    • Paolo De Los Rios
  2. Pierre Goloubinoff is at the Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

    • Pierre Goloubinoff

Authors

  1. Search for Paolo De Los Rios in:

  2. Search for Pierre Goloubinoff in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Pierre Goloubinoff.

About this article

Publication history

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DOI

https://doi.org/10.1038/nsmb.3283

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