Unrestrained 53BP1 activity causes fusions of dysfunctional telomeres and embryonic lethality associated with misrepair of DNA double-strand breaks in BRCA1-deficient mice. However, the physiological role of 53BP1 remains unclear, because it presumably did not evolve to carry out these pathological functions. A new report proposes that 53BP1 activity prevents hyper-resection and thereby promotes error-free DNA repair while suppressing alternative mutagenic pathways.
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References
Ceccaldi, R., Rondinelli, B. & D'Andrea, A.D. Trends Cell Biol. 26, 52–64 (2016).
Mehta, A. & Haber, J.E. Cold Spring Harb. Perspect. Biol. 6, a016428 (2014).
Mao, Z., Bozzella, M., Seluanov, A. & Gorbunova, V. Cell Cycle 7, 2902–2906 (2008).
Bunting, S.F. & Nussenzweig, A. Nat. Rev. Cancer 13, 443–454 (2013).
Ochs, F. et al. Nat. Struct. Mol. Biol. 23, 714–721 (2016).
Difilippantonio, S. et al. Nature 456, 529–533 (2008).
Dimitrova, N., Chen, Y.C., Spector, D.L. & de Lange, T. Nature 456, 524–528 (2008).
Manis, J.P. et al. Nat. Immunol. 5, 481–487 (2004).
Ward, I.M. et al. J. Cell Biol. 165, 459–464 (2004).
Cao, L. et al. Mol. Cell 35, 534–541 (2009).
Bouwman, P. et al. Nat. Struct. Mol. Biol. 17, 688–695 (2010).
Bunting, S.F. et al. Cell 141, 243–254 (2010).
Escribano-Diaz, C. & Durocher, D. EMBO Rep. 14, 665–666 (2013).
Panier, S. & Boulton, S.J. Nat. Rev. Mol. Cell Biol. 15, 7–18 (2014).
Altmeyer, M. & Lukas, J. Curr. Opin. Genet. Dev. 23, 156–165 (2013).
Fradet-Turcotte, A. et al. Nature 499, 50–54 (2013).
Gudjonsson, T. et al. Cell 150, 697–709 (2012).
Chapman, J.R., Sossick, A.J., Boulton, S.J. & Jackson, S.P. J. Cell Sci. 125, 3529–3534 (2012).
Densham, R.M. et al. Nat. Struct. Mol. Biol. (2016).
Kakarougkas, A. et al. Nucleic Acids Res. 41, 10298–10311 (2013).
Muñoz, M.C. et al. J. Biol. Chem. 287, 40618–40628 (2012).
Ray Chaudhuri, A. et al. Nature http://dx.doi.org/10.1038/nature18325 (2016).
Schlacher, K., Wu, H. & Jasin, M. Cancer Cell 22, 106–116 (2012).
Treuner, K., Helton, R. & Barlow, C. Oncogene 23, 4655–4661 (2004).
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Zong, D., Ray Chaudhuri, A. & Nussenzweig, A. More end resection is not merrier. Nat Struct Mol Biol 23, 699–701 (2016). https://doi.org/10.1038/nsmb.3274
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DOI: https://doi.org/10.1038/nsmb.3274