The importance of subtle gene regulation and epigenetics in determining complex human traits is increasingly being recognized. However, bridging the gaps between environmental, epigenetic and genetic influences and unraveling causal relationships remain a big challenge. A study now reports an example of epigenetic changes influenced by genetic factors that are involved in the regulation of lactase gene expression.
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Labrie, V. et al. Nat. Struct. Mol. Biol. 23, 566–573 (2016).
Tak, Y.G. & Farnham, P.J. Epigenetics Chromatin 8, 57 (2015).
Wang, Z., Maravelias, C. & Sibley, E. DNA Cell Biol. 25, 215–222 (2006).
Troelsen, J.T., Olsen, J., Møller, J. & Sjöström, H. Gastroenterology 125, 1686–1694 (2003).
Olds, L.C. & Sibley, E. Hum. Mol. Genet. 12, 2333–2340 (2003).
Lewinsky, R.H. et al. Hum. Mol. Genet. 14, 3945–3953 (2005).
Jensen, T.G. et al. Hum. Genet. 130, 483–493 (2011).
Wang, Y. et al. Gastroenterology 114, 1230–1236 (1998).
Imtiaz, F. et al. J. Med. Genet. 44, e89 (2007).
Jones, B.L. et al. Hum. Genet. 134, 917–925 (2015).
Tishkoff, S.A. et al. Nat. Genet. 39, 31–40 (2007).
Sheaffer, K.L. et al. Genes Dev. 28, 652–664 (2014).
Ranciaro, A. et al. Am. J. Hum. Genet. 94, 496–510 (2014).
Liebert, A. PhD thesis, University College London (2014).
Itan, Y., Jones, B.L., Ingram, C.J., Swallow, D.M. & Thomas, M.G. BMC Evol. Biol. 10, 36 (2010).
The authors declare no competing financial interests.
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Swallow, D., Troelsen, J. Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change. Nat Struct Mol Biol 23, 505–507 (2016). https://doi.org/10.1038/nsmb.3238
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