Two new studies of the CRISPR nuclease Cpf1 reveal the structural and catalytic flexibility of this leaner, meaner alternative to Cas9.
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Thanks to C. Rollie for helpful discussions. M.F.W. is supported as a Royal Society Wolfson Research Merit Award holder.
The author declares no competing financial interests.
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White, M. Cpf1 shape-shifts for streamlined CRISPR cleavage. Nat Struct Mol Biol 23, 365–366 (2016). https://doi.org/10.1038/nsmb.3225
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