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Cpf1 shape-shifts for streamlined CRISPR cleavage

Two new studies of the CRISPR nuclease Cpf1 reveal the structural and catalytic flexibility of this leaner, meaner alternative to Cas9.

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Figure 1: Structure and domain organization of the Cpf1 protein.
Figure 2: Conformational change of Cpf1 after crRNA binding.


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Thanks to C. Rollie for helpful discussions. M.F.W. is supported as a Royal Society Wolfson Research Merit Award holder.

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Correspondence to Malcolm F White.

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White, M. Cpf1 shape-shifts for streamlined CRISPR cleavage. Nat Struct Mol Biol 23, 365–366 (2016).

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