The sirtuin family protein SIRT6 is a stress-responsive NAD-dependent histone deacetylase with key roles in glucose homeostasis, DNA repair and cellular lifespan. SIRT6 is now shown to mediate deacetylation of histone H3 Lys18 specifically at pericentric chromatin, thus maintaining transcriptional silencing of satellite repeats in a manner independent of HP1 and trimethylated H3 Lys9, thereby assuring correct segregation of chromosomes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bernard, P. et al. Science 294, 2539–2542 (2001).
Sullivan, B.A. & Karpen, G.H. Nat. Struct. Mol. Biol. 11, 1076–1083 (2004).
Valgardsdottir, R. et al. Nucleic Acids Res. 36, 423–434 (2008).
Jolly, C. et al. J. Cell Biol. 164, 25–33 (2004).
Rudert, F., Bronner, S., Garnier, J.M. & Dollé, P. Mamm. Genome 6, 76–83 (1995).
Terranova, R., Sauer, S., Merkenschlager, M. & Fisher, A.G. Exp. Cell Res. 310, 344–356 (2005).
Enukashvily, N.I., Donev, R., Waisertreiger, I.S. & Podgornaya, O.I. Cytogenet. Genome Res. 118, 42–54 (2007).
Ting, D.T. et al. Science 331, 593–596 (2011).
Tasselli, L. et al. Nat. Struct. Mol. Biol. 23, 434–440 (2016).
Zhong, L. et al. Cell 140, 280–293 (2010).
Kaidi, A., Weinert, B.T., Choudhary, C. & Jackson, S.P. Science 329, 1348–1353 (2010).
Mao, Z. et al. Science 332, 1443–1446 (2011).
Toiber, D. et al. Mol. Cell 51, 454–468 (2013).
Kanfi, Y. et al. Nature 483, 218–221 (2012).
Sebastián, C. et al. Cell 151, 1185–1199 (2012).
Michishita, E. et al. Nature 452, 492–496 (2008).
Michishita, E. et al. Cell Cycle 8, 2664–2666 (2009).
Barber, M.F. et al. Nature 487, 114–118 (2012).
Oberdoerffer, P. et al. Cell 135, 907–918 (2008).
Mozzetta, C., Boyarchuk, E., Pontis, J. & Ait-Si-Ali, S. Nat. Rev. Mol. Cell Biol. 16, 499–513 (2015).
Peters, A.H. et al. Cell 107, 323–337 (2001).
Zhang, W. et al. Science 348, 1160–1163 (2015).
Van Meter, M. et al. Nat. Commun. 23, 5011 (2014).
Shumaker, D.K. et al. Proc. Natl. Acad. Sci. USA 103, 8703–8708 (2006).
Tsurumi, A. & Li, W.X. Epigenetics 7, 680–688 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Pastor, B., Mostoslavsky, R. SIRT6: a new guardian of mitosis. Nat Struct Mol Biol 23, 360–362 (2016). https://doi.org/10.1038/nsmb.3222
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.3222
