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Translocation: lights, camera, and action

Nature Structural & Molecular Biology volume 23, pages 367368 (2016) | Download Citation

The fundamental mechanics of how EF-G catalyzes translocation of the mRNA and tRNA pairs on the ribosome has been intensely studied for over three decades. Two kinetic studies now reveal the sequence of events and the timing of key conformational changes in the ribosome during translocation and identify new intermediates in this complex process.

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Author information

Affiliations

  1. Xinying Shi and Simpson Joseph are at the Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.

    • Xinying Shi
    •  & Simpson Joseph

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Simpson Joseph.

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DOI

https://doi.org/10.1038/nsmb.3219

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