Three recent reports explore how PRDM9 binds to meiotic hotspots within the genome and provide compelling evidence that hotspot erosion leads to speciation.
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Evolution of the recombination regulator PRDM9 in minke whales
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References
Baudat, F., Imai, Y. & de Massy, B. Nat. Rev. Genet. 14, 794–806 (2013).
Boulton, A., Myers, R.S. & Redfield, R.J. Proc. Natl. Acad. Sci. USA 94, 8058–8063 (1997).
Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J.C. & Forejt, J. Science 323, 373–375 (2009).
Bhattacharyya, T. et al. Proc. Natl. Acad. Sci. USA 110, E468–E477 (2013).
Smagulova, F., Brick, K., Pu, Y., Camerini-Otero, R.D. & Petukhova, G.V. Genes Dev. 30, 266–280 (2016).
Smagulova, F. et al. Nature 472, 375–378 (2011).
Patel, A., Horton, J.R., Wilson, G.G., Zhang, X. & Cheng, X. Genes Dev. 30, 257–265 (2016).
Pratto, F. et al. Science 346, 1256442 (2014).
Baker, C.L. et al. PLoS Genet. 11, e1004916 (2015).
Brick, K., Smagulova, F., Khil, P., Camerini-Otero, R.D. & Petukhova, G.V. Nature 485, 642–645 (2012).
Davies, B. et al. Nature 530, 171–176 (2016).
Baker, C.L. et al. PLoS Genet. 11, e1005512 (2015).
Baker, C.L., Walker, M., Kajita, S., Petkov, P.M. & Paigen, K. Genome Res. 24, 724–732 (2014).
Goldman, A.S. & Lichten, M. Proc. Natl. Acad. Sci. USA 97, 9537–9542 (2000).
Flachs, P. et al. PLoS Genet. 8, e1003044 (2012).
Hayashi, K., Yoshida, K. & Matsui, Y. Nature 438, 374–378 (2005).
Singhal, S. et al. Science 350, 928–932 (2015).
Choi, K. et al. Nat. Genet. 45, 1327–1336 (2013).
Auton, A. et al. PLoS Genet. 9, e1003984 (2013).
Axelsson, E. et al. Genome Res. 22, 51–63 (2012).
Narasimhan, V.M. et al. Science http://dx.doi.org/10.1126/science.aac8624 (2016).
Acknowledgements
Support from the Cancer Prevention and Research Institute of Texas award R1213 (F.C.), the Jeanne F. Shelby Scholarship Fund and R. Lee Clark Fellowship (F.C.), and the National Institutes of Health (NIH) grant DP2HD087943 (F.C.) is gratefully acknowledged.
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Zelazowski, M., Cole, F. X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome. Nat Struct Mol Biol 23, 267–269 (2016). https://doi.org/10.1038/nsmb.3201
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DOI: https://doi.org/10.1038/nsmb.3201
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