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X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome

Nature Structural & Molecular Biology volume 23, pages 267269 (2016) | Download Citation

Three recent reports explore how PRDM9 binds to meiotic hotspots within the genome and provide compelling evidence that hotspot erosion leads to speciation.

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Acknowledgements

Support from the Cancer Prevention and Research Institute of Texas award R1213 (F.C.), the Jeanne F. Shelby Scholarship Fund and R. Lee Clark Fellowship (F.C.), and the National Institutes of Health (NIH) grant DP2HD087943 (F.C.) is gratefully acknowledged.

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Affiliations

  1. Maciej J. Zelazowski and Francesca Cole are at the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA.

    • Maciej J Zelazowski
    •  & Francesca Cole

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Francesca Cole.

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DOI

https://doi.org/10.1038/nsmb.3201

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