Structures of the human orexin receptor 1 (hOX1R) bound to a selective drug and the dual (hOX1R- and hOX2R-targeting) antagonist suvorexant reveal molecular mechanisms of selectivity in orexin-receptor subtypes.
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Wacker, D., Roth, B. An alerting structure: human orexin receptor 1. Nat Struct Mol Biol 23, 265–266 (2016). https://doi.org/10.1038/nsmb.3198
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DOI: https://doi.org/10.1038/nsmb.3198