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An alerting structure: human orexin receptor 1

Structures of the human orexin receptor 1 (hOX1R) bound to a selective drug and the dual (hOX1R- and hOX2R-targeting) antagonist suvorexant reveal molecular mechanisms of selectivity in orexin-receptor subtypes.

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Author information

Affiliations

  1. Daniel Wacker and Bryan L. Roth are at the Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Daniel Wacker
    •  & Bryan L Roth
  2. Bryan L. Roth is also at the Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, and at the National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Bryan L Roth

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Bryan L Roth.