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Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM

Nature Structural & Molecular Biology volume 23, pages 95–97 (2016)Cite this article

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An Erratum to this article was published on 05 April 2016

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Unraveling the molecular arms race between virus and host has been taken to a new level. A cryo-EM study reveals in unprecedented detail how the herpesvirus immune-evasion protein ICP47 inhibits the peptide transporter TAP.

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Figure 1: TAP-mediated peptide transport is dependent on large conformational rearrangements.
Figure 2: Structure of the TAP–ICP47 complex based on the model by Oldham et al.1.
Figure 3: Schematic overview of the interaction between TAP and its viral inhibitors.

Change history

  • 11 February 2016

    In the version of this article initially published, the name of the first author in ref. 1 was misspelled as Oldman. The correct name is Oldham. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Rutger D. Luteijn and Emmanuel J.H.J. Wiertz are at the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.,

    Rutger D Luteijn & Emmanuel J H J Wiertz

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  1. Rutger D Luteijn
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  2. Emmanuel J H J Wiertz
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Correspondence to Emmanuel J H J Wiertz.

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Luteijn, R., Wiertz, E. Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM. Nat Struct Mol Biol 23, 95–97 (2016). https://doi.org/10.1038/nsmb.3168

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