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Molecular basis of HSF regulation

Two structural studies provide new insights into the mechanisms regulating the DNA binding and activation of human HSF family members.

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Figure 1: Secondary structures and key residues of the human HSF1 DNA-binding domain.
Figure 2: Topology of the DBD and HR-A/B in human HSF1 bound to DNA.

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Correspondence to Akira Nakai.

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Nakai, A. Molecular basis of HSF regulation. Nat Struct Mol Biol 23, 93–95 (2016). https://doi.org/10.1038/nsmb.3165

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