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N6-methyladenosine–encoded epitranscriptomics

Nature Structural & Molecular Biology volume 23, pages 98–102 (2016)Cite this article

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Abstract

N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m6A modification, which affects many different stages of the RNA life cycle.

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Figure 1: m6A epitranscriptomics: writers, erasers and readers.
Figure 2: m6A switches.
Figure 3: m6A-regulated RNA metabolism in mammalian cells.

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Acknowledgements

Research on RNA modifications in the laboratory of T.P. is supported by the US National Institutes of Health (EUREKA R01GM88599 and R01GM113194).

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Authors and Affiliations

  1. Department of Chemistry, University of Chicago, Chicago, Illinois, USA

    Nian Liu

  2. Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, Illinois, USA

    Tao Pan

  3. Institute of Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA

    Tao Pan

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Correspondence to Nian Liu or Tao Pan.

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Liu, N., Pan, T. N6-methyladenosine–encoded epitranscriptomics. Nat Struct Mol Biol 23, 98–102 (2016). https://doi.org/10.1038/nsmb.3162

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