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Motoring toward pre-60S-ribosome export

Rea1 is an ATPase related to dynein motor proteins that has been implicated in the biogenesis of the 60S ribosomal subunit. A new cryo-EM study vividly demonstrates the power of structural methods, deciphering the role of Rea1 in monitoring key pre-60S maturation steps before the acquisition of export competence in budding yeast.

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Figure 1: The pre-60S-biogenesis pathway.

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Correspondence to David Tollervey.

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Shchepachev, V., Tollervey, D. Motoring toward pre-60S-ribosome export. Nat Struct Mol Biol 23, 3–4 (2016). https://doi.org/10.1038/nsmb.3154

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