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Motoring toward pre-60S-ribosome export

Nature Structural & Molecular Biology volume 23, pages 3–4 (2016)Cite this article

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Rea1 is an ATPase related to dynein motor proteins that has been implicated in the biogenesis of the 60S ribosomal subunit. A new cryo-EM study vividly demonstrates the power of structural methods, deciphering the role of Rea1 in monitoring key pre-60S maturation steps before the acquisition of export competence in budding yeast.

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Figure 1: The pre-60S-biogenesis pathway.

References

  1. Narla, A. & Ebert, B.L. Blood 115, 3196–3205 (2010).

    Article  CAS  Google Scholar 

  2. Montanaro, L., Treré, D. & Derenzini, M. Biochim. Biophys. Acta 1825, 101–110 (2012).

    CAS  PubMed  Google Scholar 

  3. Brighenti, E., Treré, D. & Derenzini, M. Oncotarget 6, 38617–38627 (2015).

    Article  Google Scholar 

  4. Warner, J.R. Trends Biochem. Sci. 24, 437–440 (1999).

    Article  CAS  Google Scholar 

  5. Woolford, J.L. Jr. & Baserga, S.J. Genetics 195, 643–681 (2013).

    Article  CAS  Google Scholar 

  6. Strunk, B.S. & Karbstein, K. RNA 15, 2083–2104 (2009).

    Article  CAS  Google Scholar 

  7. Matsuo, Y. et al. Nature 505, 112–116 (2014).

    Article  Google Scholar 

  8. Bassler, J. et al. Mol. Cell 38, 712–721 (2010).

    Article  CAS  Google Scholar 

  9. Nissan, T.A., Bassler, J., Petfalski, E., Tollervey, D. & Hurt, E. EMBO J. 21, 5539–5547 (2002).

    Article  CAS  Google Scholar 

  10. Galani, K., Nissan, T.A., Petfalski, E., Tollervey, D. & Hurt, E. J. Biol. Chem. 279, 55411–55418 (2004).

    Article  CAS  Google Scholar 

  11. Baßler, J. et al. J. Cell Biol. 207, 481–498 (2014).

    Article  Google Scholar 

  12. Ulbrich, C. et al. Cell 138, 911–922 (2009).

    Article  CAS  Google Scholar 

  13. Nissan, T.A. et al. Mol. Cell 15, 295–301 (2004).

    Article  CAS  Google Scholar 

  14. Barrio-Garcia, C. et al. Nat. Struct. Mol. Biol. 23, 37–44 (2016).

    Article  CAS  Google Scholar 

  15. Leidig, C. et al. Nat. Commun. 5, 3491 (2014).

    Article  Google Scholar 

  16. Bradatsch, B. et al. Nat. Struct. Mol. Biol. 19, 1234–1241 (2012).

    Article  CAS  Google Scholar 

  17. Hopfield, J.J. Proc. Natl. Acad. Sci. USA 71, 4135–4139 (1974).

    Article  CAS  Google Scholar 

  18. Houseley, J. & Tollervey, D. Cell 136, 763–776 (2009).

    Article  CAS  Google Scholar 

  19. Kressler, D., Hurt, E. & Bassler, J. Biochim. Biophys. Acta 1803, 673–683 (2010).

    Article  CAS  Google Scholar 

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  1. Vadim Shchepachev and David Tollervey are at the Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.,

    Vadim Shchepachev & David Tollervey

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  1. Vadim Shchepachev
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  2. David Tollervey
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Correspondence to David Tollervey.

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Shchepachev, V., Tollervey, D. Motoring toward pre-60S-ribosome export. Nat Struct Mol Biol 23, 3–4 (2016). https://doi.org/10.1038/nsmb.3154

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