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A timer to coordinate substrate processing by the 26S proteasome

The eukaryotic 26S proteasome is responsible for degrading virtually any protein with an appropriate ubiquitin signal, and in the process ubiquitin is spared and recycled. Two studies of the proteasome-associated deubiquitinase UBP6 now shed light on how deubiquitination coordinates the cycle of substrate processing.

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Figure 1: Deubiquitination by RPN11 and UBP6 coordinates the cycle of substrate processing.

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Correspondence to Tingting Yao.

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Yao, T. A timer to coordinate substrate processing by the 26S proteasome. Nat Struct Mol Biol 22, 652–653 (2015).

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