Recent progress has greatly increased the understanding of telomere-bound shelterin proteins and the telomerase holoenzyme, predominantly as separate complexes. Pioneering studies have begun to investigate the requirements for shelterin-telomerase interaction. From this vantage point, focusing on human cells, we review and discuss models for how telomerase and shelterin subunits coordinate to achieve balanced telomere-length homeostasis.
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We thank A. Wu and J. Boyle for comments and the US National Institutes of Health (RCA196884A (D.H.) and HL0795985 (K.C.)) for funding.
The authors declare no competing financial interests.
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Hockemeyer, D., Collins, K. Control of telomerase action at human telomeres. Nat Struct Mol Biol 22, 848–852 (2015). https://doi.org/10.1038/nsmb.3083
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