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Light-driven Na+ pumps as next-generation inhibitory optogenetic tools

The first structures of a light-driven sodium pump provide insight into the mechanism of ion transport and selectivity. Genetic manipulation of rat neuronal cells and of Caenorhabditis elegans worms demonstrates the utility of such pumps for optogenetic applications.

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Figure 1: Retinal-binding proteins used as optogenetic tools.
Figure 2: Kr2 cavities as part of the ion-translocation pathway.


  1. Deisseroth, K. Sci. Am. 303, 48–55 (2010).

    Article  Google Scholar 

  2. Nagel, G. et al. Science 296, 2395–2398 (2002).

    Article  CAS  Google Scholar 

  3. Nagel, G. et al. Proc. Natl. Acad. Sci. USA 100, 13940–13945 (2003).

    Article  CAS  Google Scholar 

  4. Schobert, B. & Lanyi, J.K. J. Biol. Chem. 257, 10306–10313 (1982).

    CAS  PubMed  Google Scholar 

  5. Inoue, K. et al. Nat. Commun. 4, 1678 (2013).

    Article  Google Scholar 

  6. Gushchin, I. et al. Nat. Struct. Mol. Biol. 22, 390–395 (2015).

    Article  CAS  Google Scholar 

  7. Kato, H.E. et al. Nature doi:10.1038/nature14322 (6 April 2015).

  8. Nat. Methods 8, 1 (2011).

  9. News Staff. Science 330, 1612–1613 (2010).

  10. Kravitz, A.V. et al. Nature 466, 622–626 (2010).

    Article  CAS  Google Scholar 

  11. Häusser, M. Nat. Methods 11, 1012–1014 (2014).

    Article  Google Scholar 

  12. Kato, H.E. et al. Nature 482, 369–374 (2012).

    Article  CAS  Google Scholar 

  13. Lin, J.Y., Knutsen, P.M., Muller, A., Kleinfeld, D. & Tsien, R.Y. Nat. Neurosci. 16, 1499–1508 (2013).

    Article  CAS  Google Scholar 

  14. Berndt, A., Lee, S.Y., Ramakrishnan, C. & Deisseroth, K. Science 344, 420–424 (2014).

    Article  CAS  Google Scholar 

  15. Wietek, J. et al. Science 344, 409–412 (2014).

    Article  CAS  Google Scholar 

  16. Wickstrand, C., Dods, R., Royant, A. & Neutze, R. Biochim. Biophys. Acta 1850, 536–553 (2015).

    Article  CAS  Google Scholar 

  17. Lodish, H.F. Molecular Cell Biology (W.H. Freeman, 2000).

    Google Scholar 

  18. Kolbe, M., Besir, H., Essen, L.O. & Oesterhelt, D. Science 288, 1390–1396 (2000).

    Article  CAS  Google Scholar 

  19. Ho, B.K. & Gruswitz, F. BMC Struct. Biol. 8, 49 (2008).

    Article  Google Scholar 

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Correspondence to Jörg Standfuss.

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Nogly, P., Standfuss, J. Light-driven Na+ pumps as next-generation inhibitory optogenetic tools. Nat Struct Mol Biol 22, 351–353 (2015).

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