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Methylation gets into rhythm with NAD+-SIRT1

Nature Structural & Molecular Biology volume 22, pages 275–277 (2015)Cite this article

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Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.

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Figure 1: Dynamic cross-talk between cellular energy metabolism and chromatin regulation controls circadian rhythmicity of gene expression.

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Authors and Affiliations

  1. Luisa Tasselli and Katrin F. Chua are at the Department of Medicine, Stanford University School of Medicine, Stanford, California, USA, and the Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System Health Care System, Palo Alto, California, USA.,

    Luisa Tasselli & Katrin F Chua

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  1. Luisa Tasselli
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  2. Katrin F Chua
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Correspondence to Katrin F Chua.

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The authors declare no competing financial interests.

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Tasselli, L., Chua, K. Methylation gets into rhythm with NAD+-SIRT1. Nat Struct Mol Biol 22, 275–277 (2015). https://doi.org/10.1038/nsmb.3004

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