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Secondary nucleation wears the BRICHOS in this family

Nature Structural & Molecular Biology volume 22, pages 180–181 (2015)Cite this article

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A chaperone segment provides powerful evidence for the molecular mechanism underlying Alzheimer's disease.

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Figure 1: Proposed double nucleation for the Aβ42 assembly, highlighting the nucleation step ((1), disordered and ordered monomer shown), the structural features that favor secondary nucleation (2) and the origin of the dissociative event (3).

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  1. Frank A. Ferrone is at the Department of Physics, Drexel University, Philadelphia, Pennsylvania, USA.,

    Frank A Ferrone

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  1. Frank A Ferrone
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Correspondence to Frank A Ferrone.

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The author declares no competing financial interests.

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Ferrone, F. Secondary nucleation wears the BRICHOS in this family. Nat Struct Mol Biol 22, 180–181 (2015). https://doi.org/10.1038/nsmb.2980

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