Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism

cIAP1 undergoes a dramatic conformational change during activation that is now shown to be due to the dynamic and metastable nature of the closed form of the enzyme. The discovery of such a striking mechanism for functional control was enabled by state-of-the-art enzymological and biophysical methods.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structure of cIAP1.


  1. Phillips, A.H. et al. Nat. Struct. Mol. Biol. 21, 1068–1074 (2014).

    Article  CAS  Google Scholar 

  2. Hunter, A.M., LaCasse, E.C. & Korneluk, R.G. Apoptosis 12, 1543–1568 (2007).

    Article  CAS  Google Scholar 

  3. Vucic, D. & Fairbrother, W.J. Clin. Cancer Res. 13, 5995–6000 (2007).

    Article  CAS  Google Scholar 

  4. Vince, J.E. et al. Cell 131, 682–693 (2007).

    Article  CAS  Google Scholar 

  5. Varfolomeev, E. et al. Cell 131, 669–681 (2007).

    Article  CAS  Google Scholar 

  6. Mace, P.D. et al. J. Biol. Chem. 283, 31633–31640 (2008).

    Article  CAS  Google Scholar 

  7. Das, R. et al. EMBO J. 32, 2504–2516 (2013).

    Article  CAS  Google Scholar 

  8. Dueber, E.C. et al. Science 334, 376–380 (2011).

    Article  CAS  Google Scholar 

  9. Carr, C.M. & Kim, P.S. Cell 73, 823–832 (1993).

    Article  CAS  Google Scholar 

  10. Krumbiegel, M., Herrmann, A. & Blumenthal, R. Biophys. J. 67, 2355–2360 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to R Andrew Byrd.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gill, M., Byrd, R. Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism. Nat Struct Mol Biol 21, 1022–1023 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing