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PARP1 and CBP lose their footing in cancer

The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.

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Figure 1: Cancer cells usually lack the histone variant macroH2A.1.1; this leads to a decrease in gene expression–promoting histone acetylation (ac) at macroH2A.1-target genes.

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Acknowledgements

We acknowledge support from the Deutsche Forschungsgemeinschaft to G.T. (TI817/2-1) and to A.G.L. (SFB1064 Chromatin Dynamics), and we thank C. Laverty for comments.

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Correspondence to Andreas G Ladurner.

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Andreas Ladurner is on the Scientific Advisory Board of VolitionRx.

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Timinszky, G., Ladurner, A. PARP1 and CBP lose their footing in cancer. Nat Struct Mol Biol 21, 947–948 (2014). https://doi.org/10.1038/nsmb.2913

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