News & Views | Published:

An expanding universe of mRNA modifications

Nature Structural & Molecular Biology volume 21, pages 945946 (2014) | Download Citation

The fate of an mRNA is regulated by internal base modifications that generate the modified nucleotides N6-methyladenosine, 5-methylcytosine and inosine. Three new studies show that yeast and human mRNAs also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Cell 159, 148–162 (2014).

  2. 2.

    et al. Nature (5 September 2014).

  3. 3.

    , & PLoS ONE (29 October 2014).

  4. 4.

    & EMBO J. 17, 1120–1127 (1998).

  5. 5.

    & Cell 1, 37–42 (1974).

  6. 6.

    , & Proc. Natl. Acad. Sci. USA 71, 3971–3975 (1974).

  7. 7.

    et al. Cell 149, 1635–1646 (2012).

  8. 8.

    et al. Nature 485, 201–206 (2012).

  9. 9.

    et al. Nucleic Acids Res. 40, 5023–5033 (2012).

  10. 10.

    & Nat. Biotechnol. 31, 458–464 (2013).

  11. 11.

    & Trends Biochem. Sci. 38, 210–218 (2013).

  12. 12.

    & Cell 107, 929–939 (2001).

  13. 13.

    et al. Proc. Natl. Acad. Sci. USA 97, 14311–14316 (2000).

  14. 14.

    , & Curr. Opin. Chem. Biol. 6, 835–843 (2002).

  15. 15.

    et al. Nucleic Acids Res. 40, D306–D312 (2012).

  16. 16.

    , , & EMBO J. 30, 79–89 (2011).

  17. 17.

    et al. J. Biotechnol. 174, 16–21 (2014).

  18. 18.

    & Biochemistry 32, 9754–9762 (1993).

  19. 19.

    et al. Nat. Genet. 19, 32–38 (1998).

  20. 20.

    , , , & Am. J. Hum. Genet. 74, 1303–1308 (2004).

  21. 21.

    et al. Oncogene 31, 2794–2804 (2012).

  22. 22.

    et al. Mol. Ther. 16, 1833–1840 (2008).

  23. 23.

    & Nature 474, 395–398 (2011).

Download references

Author information

Affiliations

  1. Samie R. Jaffrey is at the Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, New York, USA.

    • Samie R Jaffrey

Authors

  1. Search for Samie R Jaffrey in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Samie R Jaffrey.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsmb.2911

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing