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An expanding universe of mRNA modifications

Nature Structural & Molecular Biology volume 21, pages 945–946 (2014)Cite this article

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The fate of an mRNA is regulated by internal base modifications that generate the modified nucleotides N6-methyladenosine, 5-methylcytosine and inosine. Three new studies show that yeast and human mRNAs also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.

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Figure 1: Pseudouridylation enzymes that introduce pseudouridine in mRNA.

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  1. Samie R. Jaffrey is at the Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, New York, USA.,

    Samie R Jaffrey

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Correspondence to Samie R Jaffrey.

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Jaffrey, S. An expanding universe of mRNA modifications. Nat Struct Mol Biol 21, 945–946 (2014). https://doi.org/10.1038/nsmb.2911

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