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Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase

Fluorescent probes at the exit channel and near the active site of RNA polymerase shed light on how transcriptional pausing is regulated.

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Figure 1: Regulated pausing during transcription elongation by RNA polymerase (RNAP) affects multiple biological processes.
Figure 2: Structural differences between the active elongation complex (left) and the paused elongation complex (right).

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Correspondence to Craig T Martin.

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Martin, C., Theis, K. Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase. Nat Struct Mol Biol 21, 741–742 (2014). https://doi.org/10.1038/nsmb.2883

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