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Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase

Nature Structural & Molecular Biology volume 21, pages 741–742 (2014)Cite this article

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Fluorescent probes at the exit channel and near the active site of RNA polymerase shed light on how transcriptional pausing is regulated.

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Figure 1: Regulated pausing during transcription elongation by RNA polymerase (RNAP) affects multiple biological processes.
Figure 2: Structural differences between the active elongation complex (left) and the paused elongation complex (right).

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Authors and Affiliations

  1. Craig T. Martin is at the Department of Chemistry, University of Massachusetts, Amherst, Amherst, Massachusetts, USA.,

    Craig T Martin

  2. Karsten Theis is at the Department of Chemical and Physical Sciences, Westfield State University, Westfield, Massachusetts, USA.,

    Karsten Theis

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  1. Craig T Martin
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  2. Karsten Theis
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Correspondence to Craig T Martin.

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The authors declare no competing financial interests.

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Martin, C., Theis, K. Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase. Nat Struct Mol Biol 21, 741–742 (2014). https://doi.org/10.1038/nsmb.2883

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