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Let it go: how to deal with a breakup in mitosis

A new report reveals how mammalian cells silence the DNA-damage response during mitosis to allow cell division to be completed in the presence of DNA lesions.

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Figure 1: Inhibition of recruitment of RNF8 and 53BP1 to DSBs during mitosis.
Figure 2: Mitotic DSB repair causes telomere fusions.


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Correspondence to Eros Lazzerini Denchi.

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Denchi, E., Li, J. Let it go: how to deal with a breakup in mitosis. Nat Struct Mol Biol 21, 433–435 (2014).

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