The exosome complex has key roles in RNA processing and quality control. Single-particle EM analyses now provide compelling evidence for two distinct pathways by which substrate RNAs can pass through the exosome structure to reach the catalytic site for exonuclease digestion.
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References
Lorentzen, E. et al. Nat. Struct. Mol. Biol. 12, 575–581 (2005).
Lorentzen, E. & Conti, E. Mol. Cell 20, 473–481 (2005).
Dziembowski, A. et al. Nat. Struct. Mol. Biol. 14, 15–22 (2007).
Schneider, C. et al. Mol. Cell 27, 324–331 (2007).
Malet, H. et al. EMBO Rep. 11, 936–942 (2010).
Bonneau, F. et al. Cell 139, 547–559 (2009).
Wasmuth, E.V. & Lima, C.D. Mol. Cell 48, 133–144 (2012).
Makino, D.L. et al. Nature 495, 70–75 (2013).
Wang, H.-W. et al. Proc. Natl. Acad. Sci. USA 104, 16844–16849 (2007).
Lorentzen, E. et al. Mol. Cell 29, 717–728 (2008).
Liu, J.-J. et al. Nat. Struct. Mol. Biol. 21, 95–102 (2014).
Gudipati, R.K. et al. Mol. Cell 48, 409–421 (2012).
Schneider, C. et al. Mol. Cell 48, 422–433 (2012).
Jia, H. et al. Proc. Natl. Acad. Sci. USA 109, 7292–7297 (2012).
Halbach, F. et al. Cell 154, 814–826 (2013).
Jackson, R.N. et al. EMBO J. 29, 2205–2216 (2010).
Weir, J.R. et al. Proc. Natl. Acad. Sci. USA 107, 12139–12144 (2010).
Schaeffer, D. et al. Nucleic Acids Res. 40, 9298–9307 (2012).
Acknowledgements
This work was supported by a Royal Society University Research Fellowship (UF100666) to C.S. and a Wellcome Trust Fellowship (077248) to D.T. Work in the Wellcome Trust Centre for Cell Biology is supported by Wellcome Trust core funding (092076).
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Schneider, C., Tollervey, D. Looking into the barrel of the RNA exosome. Nat Struct Mol Biol 21, 17–18 (2014). https://doi.org/10.1038/nsmb.2750
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DOI: https://doi.org/10.1038/nsmb.2750