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Looking into the barrel of the RNA exosome

The exosome complex has key roles in RNA processing and quality control. Single-particle EM analyses now provide compelling evidence for two distinct pathways by which substrate RNAs can pass through the exosome structure to reach the catalytic site for exonuclease digestion.

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Figure 1: Structural conformers of Rrp44 within the exosome complex.
Figure 2: Sites of RNA entry into the exosome complex.

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Acknowledgements

This work was supported by a Royal Society University Research Fellowship (UF100666) to C.S. and a Wellcome Trust Fellowship (077248) to D.T. Work in the Wellcome Trust Centre for Cell Biology is supported by Wellcome Trust core funding (092076).

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Correspondence to Claudia Schneider or David Tollervey.

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Schneider, C., Tollervey, D. Looking into the barrel of the RNA exosome. Nat Struct Mol Biol 21, 17–18 (2014). https://doi.org/10.1038/nsmb.2750

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