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A role for eIF4AII in microRNA–mediated mRNA silencing

Nature Structural & Molecular Biology volume 20, pages 543–545 (2013)Cite this article

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A recent study on the mechanism of microRNA–mediated gene silencing suggests that microRNA–induced silencing complexes inhibit ribosome scanning by recruiting the DEAD-box RNA helicase eIF4AII through an interaction with the NOT1 subunit of the CCR4–NOT deadenylase complex.

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Figure 1: miRISCs repress translation by depositing a roadblock for scanning ribosomes.

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Authors and Affiliations

  1. Elisa Izaurralde is at the Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen, Germany.,

    Elisa Izaurralde

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  1. Elisa Izaurralde
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Correspondence to Elisa Izaurralde.

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Izaurralde, E. A role for eIF4AII in microRNA–mediated mRNA silencing. Nat Struct Mol Biol 20, 543–545 (2013). https://doi.org/10.1038/nsmb.2582

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