BAK is a proapoptotic BCL-2–family protein that resides in the mitochondrial outer membrane and transforms into a toxic oligomeric pore in response to overwhelming cellular stress. Biochemical and structural analyses of hydrocarbon-stapled signaling peptides in complex with BAK establish a direct mechanism for BAK activation.
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References
Uren, R.T. et al. J. Cell Biol. 177, 277–287 (2007).
Willis, S.N. et al. Science 315, 856–859 (2007).
Cheng, E.H. et al. Mol. Cell 8, 705–711 (2001).
Kuwana, T. et al. Cell 111, 331–342 (2002).
Letai, A. et al. Cancer Cell 2, 183–192 (2002).
Lovell, J.F. et al. Cell 135, 1074–1084 (2008).
Walensky, L.D. et al. Mol. Cell 24, 199–210 (2006).
Wei, M.C. et al. Genes Dev. 14, 2060–2071 (2000).
Moldoveanu, T. et al. Nat. Struct. Mol. Biol. 20, 589–597 (2013).
Sattler, M. et al. Science 275, 983–986 (1997).
Oltersdorf, T. et al. Nature 435, 677–681 (2005).
Walensky, L.D. et al. Science 305, 1466–1470 (2004).
Du, H. et al. J. Biol. Chem. 286, 491–501 (2011).
Leshchiner, E.S., Braun, C.R., Bird, G.H. & Walensky, L.D. Proc. Natl. Acad. Sci. USA 110, E986–E995 (2013).
Dai, H. et al. J. Cell Biol. 194, 39–48 (2011).
Czabotar, P.E. et al. Cell 152, 519–531 (2013).
Suzuki, M., Youle, R.J. & Tjandra, N. Cell 103, 645–654 (2000).
Gavathiotis, E. et al. Nature 455, 1076–1081 (2008).
Gavathiotis, E., Reyna, D.E., Davis, M.L., Bird, G.H. & Walensky, L.D. Mol. Cell 40, 481–492 (2010).
Gavathiotis, E., Reyna, D.E., Bellairs, J.A., Leshchiner, E.S. & Walensky, L.D. Nat. Chem. Biol. 8, 639–645 (2012).
Souers, A.J. et al. Nat. Med. 19, 202–208 (2013).
Liu, Q. et al. J. Biol. Chem. 285, 19615–19624 (2010).
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E.D. Smith is acknowledged for assistance with figure preparation.
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L.D.W. is a scientific advisory board member and consultant for Aileron Therapeutics.
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Walensky, L. Direct BAKtivation. Nat Struct Mol Biol 20, 536–538 (2013). https://doi.org/10.1038/nsmb.2579
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DOI: https://doi.org/10.1038/nsmb.2579
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