Self-assembly of the COPII coat proteins Sec13 and Sec31 creates a spherical cage that drives vesicle formation from the endoplasmic reticulum. A multipronged approach now provides a convincing pseudoatomic model of the assembled cage that sharpens our understanding of the architecture, contact sites and flexibility of this remarkable structure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kirchhausen, T. Nat. Rev. Mol. Cell Biol. 1, 187–198 (2000).
Noble, A.J. et al. Nat. Struct. Mol. Biol. 20, 167–173 (2013).
Dannhauser, P.N. & Ungewickell, E.J. Nat. Cell Biol. 14, 634–639 (2012).
Fath, S., Mancias, J.D., Bi, X. & Goldberg, J. Cell 129, 1325–1336 (2007).
Stagg, S.M. et al. Nature 439, 234–238 (2006).
Stagg, S.M. et al. Cell 134, 474–484 (2008).
Copic, A., Latham, C.F., Horlbeck, M.A., D'Arcangelo, J.G. & Miller, E.A. Science 335, 1359–1362 (2012).
Elrod-Erickson, M.J. & Kaiser, C.A. Mol. Biol. Cell 7, 1043–1058 (1996).
Fotin, A. et al. Nature 432, 573–579 (2004).
Bi, X., Mancias, J.D. & Goldberg, J. Dev. Cell 13, 635–645 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Miller, E. The COPII cage sharpens its image. Nat Struct Mol Biol 20, 139–140 (2013). https://doi.org/10.1038/nsmb.2507
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.2507
