Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A popular engagement at the ends

Nature Structural & Molecular Biology volume 20, pages 10–12 (2013)Cite this article

Subjects

Three recent studies converged on a specific protein-protein interface between TPP1 and telomerase as being crucial for the regulation of both telomerase recruitment and processivity in mammalian cells. An equivalent interaction appears to exist in budding yeast, making this a nearly universal means of telomerase regulation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The telomere-telomerase interaction network in budding yeast and mammals.
Figure 2: The telomerase-binding surface of Tpp1 and Saccharomyces cerevisiae Est3.

References

  1. de Jesus, B.B. & Blasco, M.A. Curr. Opin. Cell Biol. published online, doi:10.1016/j.ceb.2012.09.004 (18 October 2012).

  2. Shay, J.W. & Wright, W.E. Semin. Cancer Biol. 21, 349–353 (2011).

    Article  CAS  Google Scholar 

  3. Zhong, F.L. et al. Cell 150, 481–494 (2012).

    Article  CAS  Google Scholar 

  4. Sexton, A.N., Youmans, D.T. & Collins, K. J. Biol. Chem. 287, 34455–34464 (2012).

    Article  CAS  Google Scholar 

  5. Nandakumar, J. et al. Nature 491, 285–289 (2012).

    Article  Google Scholar 

  6. Yu, E.Y., Wang, F., Lei, M. & Lue, N.F. Nat. Struct. Mol. Biol. 15, 985–989 (2008).

    Article  Google Scholar 

  7. Lee, J., Mandell, E.K., Tucey, T.M., Morris, D.K. & Lundblad, V. Nat. Struct. Mol. Biol. 15, 990–997 (2008).

    Article  CAS  Google Scholar 

  8. Lue, N.F. Trends Biochem. Sci. 35, 8–17 (2010).

    Article  CAS  Google Scholar 

  9. Pennock, E., Buckley, K. & Lundblad, V. Cell 104, 387–396 (2001).

    Article  CAS  Google Scholar 

  10. Wu, Y. & Zakian, V.A. Proc. Natl. Acad. Sci. USA 108, 20362–20369 (2011).

    Article  CAS  Google Scholar 

  11. Sfeir, A. & de Lange, T. Science 336, 593–597 (2012).

    Article  CAS  Google Scholar 

  12. Abreu, E. et al. Mol. Cell. Biol. 30, 2971–2982 (2010).

    Article  CAS  Google Scholar 

  13. Wang, F. et al. Nature 445, 506–510 (2007).

    Article  CAS  Google Scholar 

  14. Takai, K.K., Kibe, T., Donigian, J.R., Frescas, D. & de Lange, T. Mol. Cell 44, 647–659 (2011).

    Article  CAS  Google Scholar 

  15. Horvath, M.P. Crit. Rev. Biochem. Mol. Biol. 46, 409–435 (2011).

    Article  CAS  Google Scholar 

  16. Zaug, A.J., Podell, E.R., Nandakumar, J. & Cech, T.R. Genes Dev. 24, 613–622 (2010).

    Article  CAS  Google Scholar 

  17. Robart, A.R. & Collins, K. Mol. Cell 42, 308–318 (2011).

    Article  CAS  Google Scholar 

  18. Hughes, T.R., Evans, S.K., Weilbaecher, R.G. & Lundblad, V. Curr. Biol. 10, 809–812 (2000).

    Article  CAS  Google Scholar 

  19. Lee, J., Mandell, E.K., Rao, T., Wuttke, D.S. & Lundblad, V. Nucleic Acids Res. 38, 2279–2290 (2010).

    Article  CAS  Google Scholar 

  20. Hsu, M., Yu, E.Y., Singh, S.M. & Lue, N.F. Eukaryot. Cell 6, 1330–1338 (2007).

    Article  CAS  Google Scholar 

  21. Talley, J.M., DeZwaan, D.C., Maness, L.D., Freeman, B.C. & Friedman, K.L. J. Biol. Chem. 286, 26431–26439 (2011).

    Article  CAS  Google Scholar 

  22. Yen, W.F., Chico, L., Lei, M. & Lue, N.F. Proc. Natl. Acad. Sci. USA 108, 20370–20375 (2011).

    Article  CAS  Google Scholar 

  23. Paeschke, K. et al. Nat. Struct. Mol. Biol. 15, 598–604 (2008).

    Article  CAS  Google Scholar 

  24. Miyoshi, T., Kanoh, J., Saito, M. & Ishikawa, F. Science 320, 1341–1344 (2008).

    Article  CAS  Google Scholar 

  25. Moser, B.A., Chang, Y.T., Kosti, J. & Nakamura, T.M. Nat. Struct. Mol. Biol. 18, 1408–1413 (2011).

    Article  CAS  Google Scholar 

  26. Linger, B.R., Morin, G.B. & Price, C.M. Mol. Biol. Cell 22, 4161–4170 (2011).

    Article  CAS  Google Scholar 

  27. Hwang, H., Buncher, N., Opresko, P.L. & Myong, S. Structure 20, 1872–1880 (2012).

    Article  CAS  Google Scholar 

  28. Chen, C.C., Hwang, J.K. & Yang, J.M. Nucleic Acids Res. 34, W152–W157 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neal F. Lue and Eun Young Yu are in the Department of Microbiology and Immunology, W.R. Hearst Microbiology Research Center, Weill Medical College of Cornell University, New York, New York, USA.,

    Neal F. Lue & Eun Young Yu

  2. Ming Lei is at the State Key Laboratory of Molecular Biology and the National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.,

    Ming Lei

Authors
  1. Neal F. Lue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eun Young Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ming Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neal F. Lue.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lue, N., Yu, E. & Lei, M. A popular engagement at the ends. Nat Struct Mol Biol 20, 10–12 (2013). https://doi.org/10.1038/nsmb.2483

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2483

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing