Abstract
Although genomes are defined by their sequence, the linear arrangement of nucleotides is only their most basic feature. A fundamental property of genomes is their topological organization in three-dimensional space in the intact cell nucleus. The application of imaging methods and genome-wide biochemical approaches, combined with functional data, is revealing the precise nature of genome topology and its regulatory functions in gene expression and genome maintenance. The emerging picture is one of extensive self-enforcing feedback between activity and spatial organization of the genome, suggestive of a self-organizing and self-perpetuating system that uses epigenetic dynamics to regulate genome function in response to regulatory cues and to propagate cell-fate memory.
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Marina Corral
Marina Corral
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Acknowledgements
G.C. was supported by the European Research Council (ERC-2008-AdG No 232947), the Centre National de la Recherche Scientifique, the European Network of Excellence EpiGeneSys and the Agence Nationale de la Recherche. T.M. was supported by the Intramural Research Program of the US National Institutes of Health, the National Cancer Institute, the Center for Cancer Research.
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Cavalli, G., Misteli, T. Functional implications of genome topology. Nat Struct Mol Biol 20, 290–299 (2013). https://doi.org/10.1038/nsmb.2474
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DOI: https://doi.org/10.1038/nsmb.2474
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