Three structures were recently reported for tyrosyl DNA phosphodiesterase 2 (Tdp2), a protein that protects the metazoan genome from shredding following abortive topoisomerase activity. The physiological significance of these findings is discussed here.
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Caldecott, K. Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose. Nat Struct Mol Biol 19, 1212–1213 (2012). https://doi.org/10.1038/nsmb.2455
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DOI: https://doi.org/10.1038/nsmb.2455
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