Ancient, giant riboswitches at atomic resolution

Two recent reports on the structures of cobalamin riboswitches uncover amazing details on how a ubiquitous riboswitch class selectively grips a large and ancient coenzyme, revealing that some variants in this class have evolved to detect a different metabolite target.

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Figure 1: Schematic representation of the riboswitch-binding sites for AdoCbl (left) and AqCbl (right).


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RNA research in the author's laboratory is supported by the US National Institutes of Health and by the Howard Hughes Medical Institute.

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Correspondence to Ronald R Breaker.

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The author is a cofounder of BioRelix, which has licensed riboswitch intellectual property from Yale University.

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Breaker, R. Ancient, giant riboswitches at atomic resolution. Nat Struct Mol Biol 19, 1208–1209 (2012).

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