Ancient, giant riboswitches at atomic resolution

Two recent reports on the structures of cobalamin riboswitches uncover amazing details on how a ubiquitous riboswitch class selectively grips a large and ancient coenzyme, revealing that some variants in this class have evolved to detect a different metabolite target.

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Figure 1: Schematic representation of the riboswitch-binding sites for AdoCbl (left) and AqCbl (right).

References

  1. 1

    Nahvi, A. et al. Chem. Biol. 9, 1043–1049 (2002).

  2. 2

    Winkler, W., Nahvi, A. & Breaker, R.R. Nature 419, 952–956 (2002).

  3. 3

    Mironov, A.S. et al. Cell 111, 747–756 (2002).

  4. 4

    Winkler, W.C., Cohen-Chalamish, S. & Breaker, R.R. Proc. Natl. Acad. Sci. USA 99, 15908–15913 (2002).

  5. 5

    Peselis, A. & Serganov, A. Nat. Struct. Mol. Biol. 19, 1182–1184 (2012).

  6. 6

    Johnson, J.E. Jr., Reyes, F.E., Polaski, J.T. & Batey, R.T. Nature published online, doi:10.1038/nature11607 (14 October 2012).

  7. 7

    Breaker, R.R. Mol. Cell 43, 867–879 (2011).

  8. 8

    Nahvi, A., Barrick, J.E. & Breaker, R.R. Nucleic Acids Res. 32, 143–150 (2004).

  9. 9

    Roth, A. et al. Nat. Struct. Mol. Biol. 14, 308–317 (2007).

  10. 10

    Golding, B.T. & Buckel, W. in Comprehensive Biological Catalysis Vol. 3 (ed. Sinott, M.) 239–259 (Academic Press Ltd., 1998).

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Acknowledgements

RNA research in the author's laboratory is supported by the US National Institutes of Health and by the Howard Hughes Medical Institute.

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Correspondence to Ronald R Breaker.

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Competing interests

The author is a cofounder of BioRelix, which has licensed riboswitch intellectual property from Yale University.

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Breaker, R. Ancient, giant riboswitches at atomic resolution. Nat Struct Mol Biol 19, 1208–1209 (2012). https://doi.org/10.1038/nsmb.2453

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