News & Views | Published:

Context is everything: activators can also repress

Nature Structural & Molecular Biology volume 19, pages 973975 (2012) | Download Citation

Maintenance of genome integrity, cell division and gene expression have all been shown to be regulated by the condensation of DNA into heterochromatin. In a study published in this issue, Bulut-Karslioglu et al. reveal a new heterochromatin function for transcription factors in a mammalian system. They show that instead of activating gene expression, in the context of heterochromatic repeats, specific transcription factors are necessary for the maintenance of transcriptional repression and heterochromatin.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Struct. Mol. Biol. 19, 1023–1030 (2012).

  2. 2.

    & Cell. Mol. Life Sci. 62, 2711–2726 (2005).

  3. 3.

    et al. Nature 410, 120–124 (2001).

  4. 4.

    , , , & Nature 410, 116–120 (2001).

  5. 5.

    & Trends Genet. 18, 252–258 (2002).

  6. 6.

    & Curr. Opin. Genet. Dev. 10, 199–203 (2000).

  7. 7.

    et al. Science 297, 1833–1837 (2002).

  8. 8.

    , & EMBO J. 16, 5280–5288 (1997).

  9. 9.

    , & Science 304, 1971–1976 (2004).

  10. 10.

    , & Nucleic Acids Res. 21, 4886–4892 (1993).

  11. 11.

    & Biochemistry 43, 5011–5021 (2004).

Download references

Author information

Affiliations

  1. Richard Festenstein and Jackson P. K. Chan are at the Clinical Sciences Centre, Department of Medicine, Imperial College, London, UK.

    • Richard Festenstein
    •  & Jackson P K Chan

Authors

  1. Search for Richard Festenstein in:

  2. Search for Jackson P K Chan in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard Festenstein.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsmb.2401

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing