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Pinpointing a puzzling polymerase

One of the surprising discoveries in the genomic age was the presence in plant genomes of two noncanonical DNA-dependent RNA polymerases involved in small RNA–mediated gene silencing. Two recent studies map the binding sites of RNA polymerase V, uncovering new mysteries concerning the targeting and function of this enigmatic enzyme.

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Figure 1: Pol V binding sites.


  1. Haag, J.R. & Pikaard, C.S. Nat. Rev. Mol. Cell Biol. 12, 483–492 (2011).

    Article  CAS  Google Scholar 

  2. Law, J.A. & Jacobsen, S.E. Nat. Rev. Genet. 11, 204–220 (2010).

    Article  CAS  Google Scholar 

  3. Zhong, X. et al. Nat. Struct. Mol. Biol. 19, 870–875 (2012).

    Article  CAS  Google Scholar 

  4. Wierzbicki, A.T. et al. Genes Dev. doi:10.1101/gad.197772.112, published online 1 August 2012.

    Article  CAS  Google Scholar 

  5. Douet, J., Tutois, S. & Tourmente, S. PLoS Genet. 5, e1000690 (2009).

    Article  Google Scholar 

  6. López, A., Ramirez, V., Garcia-Andrade, J., Flors, V. & Vera, P. PLoS Genet. 7, e1002434 (2011).

    Article  Google Scholar 

  7. Pontes, O., Costa-Nunes, P., Vithayathil, P. & Pikaard, C.S. Mol. Plant 2, 700–710 (2009).

    Article  CAS  Google Scholar 

  8. Mosher, R.A. et al. Nature 460, 283–286 (2009).

    Article  CAS  Google Scholar 

  9. Wierzbicki, A.T., Haag, J.R. & Pikaard, C.S. Cell 135, 635–648 (2008).

    Article  CAS  Google Scholar 

  10. Law, J.A. et al. Curr. Biol. 20, 951–956 (2010).

    Article  CAS  Google Scholar 

  11. Huettel, B. et al. EMBO J. 25, 2828–2836 (2006).

    Article  CAS  Google Scholar 

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Correspondence to Rebecca A Mosher.

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Mosher, R. Pinpointing a puzzling polymerase. Nat Struct Mol Biol 19, 865–866 (2012).

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