Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.
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The authors apologize for not citing all relevant articles, owing to length restrictions. Work in the author's laboratory was supported by the Foundation for Medical Research Foundation in France, FRM (S.M.), a Molecular Biology Organization Long-Term Fellowship (A.B.-S.), Human Frontier Science Program, French National Research Agency grants ANR BLAN-07-3-190451 and ANR-0-PCVI-0015-01, and European Commission SPINE-2.
The authors declare no competing financial interests.
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Melnikov, S., Ben-Shem, A., Garreau de Loubresse, N. et al. One core, two shells: bacterial and eukaryotic ribosomes. Nat Struct Mol Biol 19, 560–567 (2012). https://doi.org/10.1038/nsmb.2313
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