Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A 'pivotal' new rule for microRNA-mRNA interactions

Finding biologically relevant targets is a prerequisite for understanding the function of any trans regulator of gene expression, but this can be particularly challenging with microRNAs (miRNAs). A study in this issue addresses the problem by identifying a novel mode of miRNA target recognition.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparison between perfect seed match, nucleation bulge, short seed and non-nucleation bulge.


  1. Bartel, D.P. Cell 136, 215–233 (2009).

    Article  CAS  Google Scholar 

  2. Baek, D. et al. Nature 455, 64–71 (2008).

    Article  CAS  Google Scholar 

  3. Selbach, M. et al. Nature 455, 58–63 (2008).

    Article  CAS  Google Scholar 

  4. Chi, S.W., Hannon, G.J. & Darnell, R.B. Nat. Struct. Mol. Biol. 19, 321–327 (2012).

    Article  CAS  Google Scholar 

  5. Chi, S.W., Zang, J.B., Mele, A. & Darnell, R.B. Nature 460, 479–486 (2009).

    Article  CAS  Google Scholar 

  6. Zisoulis, D.G. et al. Nat. Struct. Mol. Biol. 17, 173–179 (2010).

    Article  CAS  Google Scholar 

  7. Vella, M.C., Choi, E.-Y., Lin, S.-Y., Reinert, K. & Slack, F.J. Genes Dev. 18, 132–137 (2004).

    Article  CAS  Google Scholar 

  8. Didiano, D. & Hobert, O. Nat. Struct. Mol. Biol. 13, 849–851 (2006).

    Article  CAS  Google Scholar 

  9. Ha, I., Wightman, B. & Ruvkun, G. Genes Dev. 10, 3041–3050 (1996).

    Article  CAS  Google Scholar 

  10. Tay, Y., Zhang, J., Thomson, A.M., Lim, B. & Rigoutsos, I. Nature 455, 1124–1128 (2008).

    Article  CAS  Google Scholar 

  11. Bhattacharyya, S.N., Habermacher, R., Martine, U., Closs, E.I. & Filipowicz, W. Cell 125, 1111–1124 (2006).

    Article  CAS  Google Scholar 

  12. van Kouwenhove, M., Kedde, M. & Agami, R. Nat. Rev. Cancer 11, 644–656 (2011).

    Article  CAS  Google Scholar 

  13. Vasudevan, S. & Steitz, J.A. Cell 128, 1105–1118 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Frank J Slack.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stefani, G., Slack, F. A 'pivotal' new rule for microRNA-mRNA interactions. Nat Struct Mol Biol 19, 265–266 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing